This type of Rec ball is difficult for better skilled players to play without coming off as snobby. I would put your most skilled player at Setter and run a 5-1, but that's just the setter in me talking.
I would seperate your better players and have a skilled player, unskilled player, skilled player etc. You can always move them after the service whether you play 4-2, 6-2, or 5-1
I firmly believe that anyone can hit a good set, therefore, train your unskilled players to let the second ball go to the setter no matter what, and have them wait for a set so that they can hit the ball. Most unskilled players think hitting the ball is the most exciting thing about the game anyway, even if they can't put anything behind it.
If you have a good setter, your hitters can hit out of the backrow, and you can move them around to get them quality sets. Simply give the unskilled player a spot to play and go from there.
At the level you are talking about though. Attention needs to be given to "teaching" the 4-2, 5-1, 6-2, etc. Most beginner players get very angry because they don't know where they need to be and it's all so confusing at first. All of this may cause them to drop the sport and your team altogether. They don't realize that running an offense like that is much easier than standing around and getting used to a new position every rotation. It's definately a learning curve. I've even had "skilled players" yell at me for trying to teach a 5-1 in a game and they want to play "regular." You just have to and hope you can teach a little at a time. I would suggest strating with a 4-2, then 6-2, then maybe even a 5-1 depending on how they grasp it.
If your beginning players are willing to learn something new and lose a few matches in the beginning, then go for it. But if they are just there to play, you have to let them since it is Rec ball. It's ultimately up to you, you know how skilled or unskilled your players are, you also know how receptive they are to "changing the game they know."
Also, I don't mean to be sexest at all, but it's been my experience that Rec Ball female players tend to have less patience to learn an offense, no matter which one. I've always been accused by women of having too much testosterone and trying to complicate the game that they want to "have fun" with.
No matter what you choose, be careful how you come across, many rec players just want to have fun and have the middle front player set.